Research at Duke
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Torsin A Dysfunction - Dr. Nicole Calakos
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In hopes to provide new oppurtunities for the treatment and cure of dystonia, The Calakos group has proposed to use the abnormal characteristics of disease-associated TorsinA to develop a high-thorough examination with high-content readouts to screen for modifiers that will reduce the abnormal protein burden. Such information will pin-point new small molecules and pathways for the correction of pathological TorsinA activity.
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Alignment Grant Acceleration Project
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While researching DYT1 dystonia through the alignment grant funding Duke made a big discovery. In order to define the target / compound needed to bring the research to a drug discovery as efficiently as possible Tyler’s Hope has introduced the Alignment Grant Acceleration Project.
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